何肖龙
何肖龙

南方医科大学珠江医院检验医学部教授/PI

 

联系方式:18620071640

E-mail307660349@qq.com

 

研究方向:

结合功能宏基因组、代谢组和转录组等多组学技术,研究肠道菌群代谢产物与宿主疾病的关系,并致力于转化应用

益生菌作用机理研究

招生专业:

●  临床检验诊断学

 

招生层次:

●  学术型博士

●  学术型硕士

 

主持课题:

近年来主持或参与国家自然科学基金项目6项、广东省自然科学基金4项、中国博士后科学基金3项

 

代表作论文/著作: 

1.      Xiaolong He, Jie Gao, Liang Peng, Tongtong Hu, Yu Wan, Meijuan Zhou, Peilin Zhen, Hong Cao. Bacterial O-GlcNAcase genes abundance decreases in ulcerative colitis patients and its administration ameliorates colitis in mice. Gut, 2020, gutjnl-2020-322468. IF(2021)=23.059

2.      Xiaolong He, Weijun Yang, Zhijie Zeng, Yi Wei, Jie Gao, Bao Zhang, Li Li, Liqun Liu, Yu Wan, Qing Zeng, Zelong Gong, Liting Liu, Hanyun Zhang, Yubin Li, Shaojie Yang, Tongtong Hu, Lixian Wu, Eliezer Masliah, Shenghe Huang, and Hong Cao. NLRP3-dependent pyroptosis is required for HIV-1 gp120-induced neuropathology[J]. Cellular & molecular immunology, 2020, 17(3):283-299. IF(2021)=11.53

3.      Xiaolong He, Wang L, Liu L, Gao J, Long B, Chi F, Hu T, Wan Y, Gong Z, Li L, Zhen P, Zhang T, Cao H, Huang SH. Endogenous α7 nAChR Agonist SLURP1 Facilitates Escherichia coli K1 Crossing the Blood-Brain Barrier. Front Immunol. 2021, 14;12:745854. IF(2021)=7.560

4.      Xiaolong He, Xiaolu Shi, Santhosh Puthiyakunnon, Like Zhang, Qing Zeng, Yan Li, Swapna Boddu, Jiawen Qiu, Zhihao Lai, Chao Ma, Yulong Xie, Min Long, Lei Du, Sheng-He Huang, Hong Cao. CD44-mediated monocyte transmigration across Cryptococcus neoformans-infected brain microvascular endothelial cells is enhanced by HIV-1 gp41-I90 ectodomain. J Biomed Sci. 2016, 23:28. IF2021=8.410

5.      Xiaolong He, Qing Zeng, Santhosh Puthiyakunnon, Zhijie Zeng, Weijun Yang, Jiawen Qiu, Lei Du, Swapna Boddu, Tongwei Wu, Danxian Cai, Sheng-He Huang, Hong Cao. Lactobacillus rhamnosus GG supernatant enhance neonatal resistance to systemic Escherichia coli K1 infection by accelerating development of intestinal defense. Sci Rep, 2017, 6;7:43305. IF(2021)=4.379

6.      Xiaolong He, Qin Wang, Liang Peng, Ya-Rong Qu, Santhosh Puthiyakunnon, Xiao-Lu Liu, Chang Ye Hui, Swapna Boddu, Hong Cao, Sheng-He Huang. Role of uropathogenic Escherichia coli outer membrane protein T in pathogenesis of urinary tract infection. Pathog Dis. 2015, 73(3):ftv006. IF(2021)=3.166

7.      Qing Zeng, Xiaolong He (co-first author), Santhosh Puthiyakunnon, Hansen Xiao, Zelong Gong, Swapna Boddu, Lecheng Chen, Huiwen Tian, Sheng-He Huang, Hong Cao. Probiotic Mixture Golden Bifido Prevents Neonatal Escherichia coli K1 Translocation via Enhancing Intestinal Defense. Front Microbiol. 2017, 8:1798. IF(2021)=5.604

8.      Shifu Wang, Xiaolong He (co-first author), Jing-Yi Yu, Michael Neely, Lehai Zhang, Liang Peng, Xiaolu Shi, Xinpeng Li, Sulan Wang, Hong Cao, Zhongtao Gai, Sheng-He Huang. Characterisation of a multidrug-resistant meningitic Escherichia coli strain (O75:K1:H5) isolated from an infant that is sensitive to memantine, a newly identified host-directed antimicrobial drug. Int J Antimicrob Agents. 2015, 46(5):598-600. IF(2021)=5.283

9.      Jing-Yi Yu, Xiaolong He (co-first author), Santhosh Puthiyakunnon, Liang Peng, Yan Li, Li-Sha Wu, Wen-Ling Peng, Ya Zhang, Jie Gao, Yao-Yuan Zhang, Swapna Boddu, Min Long, Hong Cao, Sheng-He Huang. Mucin2 is Required for Probiotic Agents-Mediated Blocking Effects on Meningitic E. coli-Induced Pathogenicities. J Microbiol Biotechnol. 2015, 25(10):1751-60.  IF(2021)=2.351

10.  Santhosh Puthiyakunnon, Xiaolong He (co-first author), Swapna Boddu, Sheng-He Huang, Hong Cao. C-Met Inhibitors are Potential Novel Therapeutic Agents Against Listeria monocytogenes Infection Through Blocking the Bacteria Entry into Nonphagocytic Cells. Curr Top Med Chem. 2017;17(3):278-289. IF(2021)=3.259

11.  Liang Peng, Li Li, Xiaolong He (co-first author), Jing-Yi Yu, Zhi-Jie Zeng, Wei-Jun Yang, Bao Zhang, Tie-Song Zhang, Hong Cao, Sheng-He Huang, Li-Qun Liu. Memantine Displays Antimicrobial Activity by Enhancing Escherichia coli Pathogen-Induced Formation of Neutrophil Extracellular Traps[J]. Frontiers in Cellular and Infection Microbiology, 2020, 10: 47. IF(2021)=5.293

12.  Yanpeng Zhang, Zhuocheng Li, Xiaolong He, Fanglin Ding, Weiqing Wu, Yong Luo, Bing Fan, Hong Cao. Overproduction of efflux pumps caused reduced susceptibility to carbapenem under consecutive imipenem-selected stress in Acinetobacter baumannii. Infect Drug Resist, 2018, 29;11:457-467. IF=2.984

13.  Zelong Gong, Xiaolu Shi, Fang Bai, Xiaolong He, Hanyun Zhang, Yubin Li, Yu Wan, Yiman Lin, Yaqun Qiu, Qiongcheng Chen, Qinghua Hu, Hong Cao. Characterization of a novel diarrheagenic strain of Proteus mirabilis associated with food poisoning in China[J]. Frontiers in Microbiology, 2019, 10: 2810. IF=4.235

14.  Jie Gao, Yubin Li, Yu Wan, Tongtong Hu, Liting Liu, Shaojie Yang, Zelong Gong, Qing Zeng, Yi Wei, Weijun Yang, Zhijie Zeng, Xiaolong He, Sheng-He Huang, Hong Cao. A novel postbiotic from Lactobacillus rhamnosus GG with a beneficial effect on intestinal barrier function[J]. Frontiers in Microbiology, 2019, 10: 477.  IF=4.235

15.  Yubin Li, Shaojie Yang, Jingxian Lun, Jie Gao, Xuefeng Gao, Zelong Gong, Yu Wan, Xiaolong He, Hong Cao. Inhibitory Effects of the Lactobacillus rhamnosus GG Effector Protein HM0539 on Inflammatory Response Through the TLR4/MyD88/NF-кB Axis. Front Immunol. 2020, 11:551449. IF=5.085

16.  Hong Cao, Like Zhang, Xiaolong He, Min Long. HIV-1 gp41 enhances CD44-mediated monocytes migration across Cryptococcus-infected brain endothelial cells[J]. International Journal of Infectious Diseases, 2014, 21: 290. IF=3.202

 

参加会议情况:

1.  Xiaolong He, Qing Zeng, Jiawen Qiu, Sheng-He Huang, Hong Cao. Conditioned medium from  Lactobacillus rhamnosus GG enhances epithelial barrier function and protects neonatal rats against experimental hematogenous meningitis. The 16th International Symposium on Microbial Ecology (ISME 16), Montreal, Canada, August 21-26, 2016

2.      Xiaolong He, Bao Zhang, Qing Zeng, Sheng-He Huang, Hong Cao. Cleavage of vimentin is involved in E. coli K1-induced death of brain microvascular endothelial cells. 2016中华医学会微生物学和免疫学年会,广西,南宁,2016,8,11-13

3.      Xiaolong He, Qin Zeng, Qian Xie, Santhosh Puthiyakunnon, Min Long, Hong Cao*. Identification of a novel protein from Lactobacillus rhamnosus GG supernatant that exert enhancing effect on mucin production. The IUMS Congresses 2017, Singapore, Singapore, July 17-21, 2017, IUMS2017-2863

4.      Yu-Bin Li, Xiaolong He, Ze-Long Gong, Qing Zeng, Hong Cao*. Melioration of intestinal inflammation through an epidermal growth factor receptor-dependent mechanism by HM0539, a Lactobacillus rhamnosus GG-derived protein. The 17th International Symposium on Microbial Ecology (ISME 17), Leipzig, Germany, August 12-17, 2018

5.      Zhi-Jie Zeng, Yong-Jia Wang, Qian Wu, Xiaolong He, Wei-Jun Yang, Meng-Jia Yang, Rong Zhu, Jie Gao, Hong Cao*, Sheng-He Huang. The generation of a new mouse model with α7 nAChR knockout and HIV-1 gp120 overexpression. American Society for Microbiology ASM Microbe 2019, June 20-24, San Francisco, U.S.A.

6.      Ze-Long Gong, Fang Bai, Xiaolong He, Yu-Bin Li, Min Long, Xiao-Lu Shi, Hong Cao*. Exploration on diarrheal pathogenicity induced by patient-derived Proteus mirabilis infection in mice. The 8th Congress of European Microbiologist (FEMS 2019), 7-11 July 2019, Glasgow, Scotland, UK

7.      Yu-Bin Li, Xiaolong He, Yu-Wan, Ze-Long Gong, Hong Cao. A novel Lactobacillus rhamnosus GG-derived protein exerts anti-inflammation through NF-κB inactivation. The 8th Congress of European Microbiologist (FEMS 2019), 7-11 July, 2019, Glasgow, Scotland, UK.

8.      Hong Cao, Jingyi Yu, Min Long, Yan Li, Xiaolong He, Shenghe Huang. Mucin gene deficiency impairs probiotics inhibition on Escherichia coli K1 adhesion and invasion to Caco-2 cells, The IUMS Congresses, Montréal, 2014.7.27-2014.8.1.